Wesley was born in Epworth, 23 miles north-west of Lincoln. He was the fifteenth child of Samuel Wesley and his wife Susanna Wesley. Susanna provided her children with intensive home education and spiritual input.
In 1916, Amy established a Protestant religious order called the Sisters of the Common Life.
In 1912, Queen Mary recognised Amy's missionary work and helped to fund a hospital in Dohnavur.
The Dohnavur Fellowship added a home for boys, usually the babies of rescued temple prostitutes, in 1918