Simeon was from an upper middle-class family and attended Eton from the age of nine to nineteen. He was agile enough to leap over a row of six chairs, and was a skilled horseman, but no academic distinction is recorded.
In 1916, Amy established a Protestant religious order called the Sisters of the Common Life.
In 1912, Queen Mary recognised Amy's missionary work and helped to fund a hospital in Dohnavur.
The Dohnavur Fellowship added a home for boys, usually the babies of rescued temple prostitutes, in 1918